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Ritonavir or lopinavir/ritonavir greatly increase plasma concentrations of oxycodone in healthy human volunteers due to inhibition of CYP3A4 and CYP2D6.[59] Rifampicin greatly reduces plasma concentrations of oxycodone due to strong induction of CYP3A4.
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Because oxycodone is metabolized by the cytochrome P450 system in the liver, its pharmacokinetics can be influenced by genetic polymorphisms and drug interférence concerning this system, as well as by liver function.[47] Some people are fast metabolizers of oxycodone, while others are Indolent metabolizers, resulting in polymorphism-dependent alterations in proportionnelle analgesia and toxicity.
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